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Gordon: Yeah

doi: 10.3389/fimmu.2023.1301817 Received 25 September 2023 Accepted 13 November 2023 Published 23 November 2023 Volume 14 - 2023 Edited by Jian Gao, Shanghai Childrens Medical Center, China Reviewed by Yan Zhou, The First Affiliated Hospital of Xian Jiaotong University, China

In that case, diet, sleep, and gut-brain work often come first

Its deficiency results in reduced NAD + synthesis and accumulation of its substrate, NAM, leading to increased NNMT activity and further decline in NAD + levels

The question isn't whether levels decline it's whether yours have declined enough to cause symptoms

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Cooke P., Janowitz H., Dougherty S.E