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Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

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Potential Research Applications: Glucose metabolism and insulin sensitivity studies Mitochondrial function and energy regulation research Aging, longevity, and metabolic health models Exercise mimetic and fat metabolism investigations For laboratory research use only

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