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Data availability The datasets generated and analyzed during this study are included in the Supplementary files

Elevated Hcy leads to an increase in the generation of mitochondrial ROS, resulting in oxidative damage at the cellular and molecular levels, and suppression of antioxidant enzyme systems (Perna et al., 2003

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Treatment with glucose-lowering agent(s) within 90 days before screening

Patients taking blood thinners (aspirin, warfarin, or certain anticoagulants) experience prolonged bleeding into tissue, resulting in larger or darker bruises