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Multiple reproductive abnormalities, including decreased oocyte maturation, disturbed follicular development and ovulation, heightened rates of follicular atresia, and eventually infertility, are caused by conditional deletion of Dicer1 exclusively in mammalian follicular granulosa cells (GCs) [87,88,89]

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In addition, activation of VPAC receptors stimulates the production of intracellular calcium [22] and also modulates the activity of phospholipase D (PLD) [23]

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In addition to vasoprotection, oral administration of quercetin-3- O -gentiobiose (2575 mg/kg) once daily for two weeks considerably improved the endurance capability of rats against fatigue, decreased serum blood urea nitrogen (BUN) and lactic acid levels, enhanced the activities of antioxidant enzymes (SOD, glutathione peroxidase) and attenuated inflammatory cytokine levels (MCP-1, IL-6 and TNF-)