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Pyrimidinedione derivatives, known for enhanced metabolic stability, led to the potent, selective, and bioavailable DPP-4 inhibitor alogliptin

Davies MJ, Bergenstal R, Bode B, Kushner RF, Lewin A, Skjth TV, Andreasen AH, Jensen CB, DeFronzo RA, for the NN8022-1922 Study Group

& Mannucci, E

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Healthcare providers should implement gastric ultrasound screening, consider prokinetic medications like erythromycin, and maintain vigilant monitoring for early warning signs including persistent bloating, early satiety, and vomiting of undigested food