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Increased phosphate levels encourage the polarization of M1 macrophages through miRNA and RNA regulatory mechanisms, while senescent macrophages heighten local inflammation and the transdifferentiation of VSMCs via interferon signaling (50, 53)

DSIP (delta sleep-inducing peptide) is an endogenous nonapeptide first isolated in the 1970s and studied as a research tool in neuropeptide and neuroendocrine research