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It initiates a powerful downstream cascade that is sustained by endogenous mechanisms, like gene expression changes or receptor upregulation, long after the drug itself has cleared the plasma

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Mediolateral extent PEG-fused animals reliably exhibited terminal labeling (22 out of 23 cases) within the correct mediolateral boundaries established in Unoperated Control animals ( Figure 5B )

This amplification of endogenous signaling rather than exogenous receptor activation is a mechanistically distinct approach to cognitive enhancement

The study showed that there was a trend towards raised VEGF in all stages of varicose veins, but this only reached statistical significance in those with healed ulceration

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