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During the early stages of evolution, iron has emerged as the preferred centre for enzymatic reactions and energy acquisition, which is likely attributable to its abundance and diverse valence states

Astragaloside IV, is the main active component of Astragalus membranaceus (Fisch.) Bge., has been found to significantly reduce ABR deficiency in impulsive noise-induced hearing loss and reduce ROS and the expression of cas-3 by intragastric administration of astragaloside IV to guinea pigs [188]
(13) Charbonnel, B
CK2 promotes advanced glycation end products-induced expressions of fibronectin and intercellular adhesion molecule-1 via activating MRTF-A in glomerular mesangial cells

Stinchcombe 2011
