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Cardiovascular: Pulmonary edema and congestive heart failure early in treatment

Davidson and Rilsling developed a device that can generate controlled sagittal acceleration to the rat's head, resulting in DAI

(2006) noted the antimetastatic effect of epithalon, using the peptide to slow down the development of metastases from spontaneous tumors in female mice that were otherwise prone to reproductive organ tumors [8]

Perez-Vilar et al., 2005

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To directly test this idea, we first applied bleomycin to animals and 5 days later administered intrapleural AAV-Cystatin A, tracked the animals weight and investigated lungs at day 21 post bleomycin instillment (Fig