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This study analyzed heart samples from five pediatric male BTHS patients (5 months-15 years) and compared them to tissues from 24 non-failing donors (1971 years) using an integrated omics method combining metabolomics, lipidomics, and proteomics

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This cellular priming provides the mechanistic foundation for FOXO4-DRI's selective targeting, enabling researchers to eliminate senescent cells without affecting healthy tissue function

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