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Ocular Granulocytic Sarcoma: A Case Report and Literature Review of Ocular Extramedullary Acute Myeloid Leukemia

doi: 10.1136/gut.27.11.1292 238 RoyJGalanoJDurandTGuennecJLLeeJC

Numerous studies indicate that, in many tumors, flux through the reductive carboxylation pathway toward lipogenesis can exceed the flux of glutamine oxidation through the citric acid cycle 226,227,228,229

In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

The enzyme dimethylarginine dimethylaminohydrolase (DDAH) further regulates NO production by degrading asymmetric dimethylarginine (ADMA), an endogenous NOS inhibitor

The Sydney multicenter study of Parkinsons disease: the inevitability of dementia at 20 years