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The proteins significantly differentially expressed in the different groups were processed in STRING version 12.0 ( to obtain medium-confidence interaction data (score 0.7)
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The authors reported a 55.8% reduction in facial wrinkle volume and a 32.8% reduction in wrinkle depth compared with control serum, alongside in vitro evidence that GHK-Cu increased both collagen and elastin production in human dermal fibroblasts at concentrations as low as 0.01 nM [4]
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