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Phase IIb/III trials were conducted for obesity but fell short of the primary endpoint

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Recommended dosing ranges for each tier can be found under the applicable medication dropdown below

Key information was extracted from each publication (whenever relevant) on the study question, characteristics of the participants, form of intervention, biomarkers used to diagnose B12 deficiency, clinical tests, outcomes, and key findings

If you experience worsening neurological symptoms such as increasing weakness, loss of balance, or new symptoms, this requires prompt medical assessment rather than being considered part of normal adjustment

For men looking to shed excess weight, particularly abdominal fat, HCG can provide an additional boost in their efforts