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Conversely, a high NADH/NAD+ ratio favors a reduction in the number of lipoyl groups in the E2 subunit of PDHC, and at the same time, a high acetyl-CoA/CoA ratio causes its acetylation, both of which simultaneously act as allosteric activators of PDK, augmenting its phosphorylating capacity and exerting an inhibitory effect on PDHC [167]
[PubMed]^1 Franco, R., et al
doi: 10.1093/braincomms/fcaa109 312 RiviereG
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