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Central nervous system effects: The ability of SLU-PP-332 to cross the blood-brain barrier more readily may make it a better candidate for neurological indications

doi: 10.1542/peds.2011-3029

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While this trial showed trends toward fat loss in the treatment groups, the primary endpoint of statistically significant weight reduction compared to placebo was not consistently achieved across all dose groups, and effect sizes were more modest than hoped

The activation of HSL is primarily regulated by hormonal signals, especially those mediated through the cAMP pathway, where PKA plays a crucial role