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An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]

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This study utilized magnetic resonance spectroscopy (MRS) to measure real-time glutathione concentrations in the brain, and demonstrated that intranasal administration of glutathione elevates the brain glutathione level

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Halliwell B., Gutteridge J.M

[DOI] [PubMed] [Google Scholar] 534

Glutathione peroxidase of Pennisetum glaucum (PgGPx) is a functional Cd2+ dependent peroxiredoxin that enhances tolerance against salinity and drought stress