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It is proposed that the C* domain located at the C-terminus of CesAand the TE domain located at the C-terminus of CesB works as a cooperative esterification and depsipeptide elongation center, repeatedly recruiting the action of the C* domain to oligomerize tetradepsipeptides to give octa- and dodecadepsipeptides prior to macrocyclization by the TE domain

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They also corroborate pharmacological and preclinical data favoring more frequent administration of high-dose beta interferon

Standard blood test showed negligible effects of CD5/ LNP-FAPCAR 2.2 treatment on red blood cells and platelets (Table S1, S2)

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