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Next, to confirm that the xenograft lesions were indeed derived from the human cell lines (Control-imESCs or HOXC8-imESCs), the cells were immunostained for vimentin (VIM), a mesenchymal and ESC marker, and STEM101, a human-specific nuclear marker, and checked for HOXC8 signals

Collectively, these data have identified a biological difference between children who are discordant for konzo and emphasize the role of oxidative stress in neglected motor system diseases, effectively opening new venues for research into potential disease mitigation strategies

doi: 10.1016/j.neuint.2019.104516

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Compared to younger individuals, this vitamin deficiency is more common in older adults because of the higher prevalence of food-bound vitamin B 12 malabsorption (atrophic gastritis) and the higher incidence of the autoimmune condition, pernicious anemia (39)