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On the other hand, a psycho-immune-neuroendocrine network alteration, which occur through the reduction of pro-inflammatory cytokines, has also been proposed to explain the effect of antidepressants (Lu et al., 2017
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It does not broadly inhibit SAM-dependent methylation reactions, which would create significant off-target effects
[DOI: 10.1002/14651858.ED000098] [DOI] [PMC free article] [PubMed] Schnemann 2011 Schnemann HJ, Oxman AD, Higgins JPT, Vist GE, Glasziou P, Guyatt GH
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The difference between these two arginine metabolic pathways forms the basis of M1/M2 polarization of immune response
