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Hypoxia-inducible factors, including HIF-1 and HIF-2, are main regulators in adaptation to hypoxia and nutrient deprivation during tumor progression (141)

Maddalena R, Hall C, Hamilton A

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The non-enzymatic components are compounds like ascorbic acid (ASC), carotenoids, flavanoids, phenolics, reduced glutathione (GSH), and -tocopherol which act as antioxidant buffers removing higher levels of ROS and are found in all sub-cellular compartments (Miller et al., Figure 1 The stress conditions always result in an excessive production of ROS which causes a major shift in redox environment