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Researchers are also looking into new delivery methods, like nasal sprays, to enhance its effectiveness and make it more accessible for studies

However, only the 1A -AR subtype, when translocated to deeper endosomes, induces a sustained activation of ERK1/2, which was abrogated by -arrestin 2 knockdown or with the use of the endocytosis inhibitor concanavalin A (Perez-Aso et al., 2013

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Figure 1 The expression status of GHR mRNA at different follicle developmental stages was investigated in the goat, and high expression was found in oocyte, stromal, cumulus and mural granulosa cells of both small and large antral follicles (18)

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