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Overall, the position of different mutations can affect protein catalytic activity and stability to various degrees, with mutations in specific region of the protein leading to more severe deficiency

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[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Gandhirajan RK, Jain M, Walla B, Johnsen M, Bartram MP, Huynh Anh M, Rinschen MM, Benzing T, Schermer B: Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ)

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