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Chen M, Liu G, Fang Z, Gao W, Song Y, Lei L, et al

Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer

[DOI] [PubMed] [Google Scholar] 63.Kershaw EE, Hamm JK, Verhagen LAW, Peroni O, Katic M, Flier JS

Genomics 276 , 495502

used a targeted pooled CRISPR approach known as TOXCRISPR to elucidate the targets of a chiral gold(I) anticancer agent, JHK-21 (Figure 12)