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Brain Res Mol Brain Res 138: 816, 2005

Finally, although systemic exposure from intravitreal dosing is low, reviews of systemic safety note isolated reports and signalsparticularly in patients with preexisting comorbiditiesprompting continued surveillance of possible cerebrovascular, renal, or other systemic effects ( Taken together, these mechanistic and clinical observations do not argue against the clear, sight-saving benefits of anti-VEGF therapy in neovascular disease

Poon HF, Farr SA, Banks WA, Pierce WM, Klein JB, Morley JE, Butterfield DA

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The relationship of mitral annular shape to the diagnosis of mitral valve prolapse