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Accordingly, rational delivery design should favor uptake and post-endocytic routes that promote progression from early endosomes to late endosomes and lysosomes, incorporate ligands or sorting elements that enhance lysosomal trafficking, minimize features associated with retrograde transport to the Golgi or ER, avoid physicochemical properties that predispose cargos to unintended mitochondrial accumulation, and exploit lysosome-responsive triggers, such as acidic pH or lysosomal hydrolases, to improve functional specificity [144]

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Another important issue when analyzing GSH in blood is the measurement of Hb in the same samples

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The increase in IGFBP-1 and -2 leads to secondary increases in circulating IGF-I binding capacity that results in high total IGF-I, but decreased IGF-I bioactivity (77, 78) ( Figure 4 )

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