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This pathway is dysfunctional in cancer and other syndromes and is known to short circuit glycolytic intermediates towards formate in a manner similar to the Warburg pathway that diverts glycolytic intermediates to lactate instead of feeding the tricarboxylic acid (TCA) cycle 31
2004 Jan;42(1):113-6
Though it can be administered as a supplement, direct administration through injections are far more effective
10.1038/mp.2015.217 194 YoshimiN.FutamuraT.KakumotoK.SalehiA
Pathogenesis Unknown but origin from liver blastema cells, neoplastic hepatocytes, oval cells, and biliary epithelial cells proposed
