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They play diverse roles, from improving tight junction expression to modulating immune function and exerting regulatory effects on organ-specific systems through gut-organ axes

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[16] The HCELL glycoform was originally discovered on human hematopoietic stem cells and leukemic blasts, [11] [17] [18] [19] and was subsequently identified on cancer cells

Int Arch Occup Environ Health 87: 579590, 2014

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However, other strategies are showing promise, particularly antisense oligo and antibody-based approaches