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When homocysteine is too low, the production of these two heavy hitters drops, which can cause detoxification issues, nerve damage, and immune system struggles

In cellular models of PD, gallic acid has been shown to improve neuronal survival under toxin exposure

Vitamin E is a complete tumor promoter in mouse skin

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In cells containing mitochondria, ALA is reduced in an NADH-dependent reaction with lipoamide dehydrogenase to form dihydrolipoic acid (DHLA), whereas in cells that lack mitochondria, ALA can instead be reduced to DHLA via NADPH with glutathione (GSH) and thioredoxin reductases (Jones et al., 1998