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Thymosin beta 4: an emerging therapeutic candidate for kidney diseases

Additionally, MAT expression can be modulated by transcriptional regulation in response to cellular signals and metabolic demands

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Ginseng and Rhubarb combination ameliorates ferroptosis in persistent inflammation, immunosuppression, and catabolism syndrome via the CaMKII/HO-1 signaling pathway February 04, 2026: 6(2):205-219 Objective: This study aimed to investigate the therapeutic effects and underlying mechanisms of the Ginseng and Rhubarb combination (GRC) on sepsis-induced persistent inflammation, immunosuppression, and catabolism syndrome (PICS)

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Glucocorticoid regulation of corticotroph POMC transcription is also indirectly mediated via other mechanisms such as down-regulation of c-jun expression and direct protein-protein mediated inhibition of CRH-induced AP-1 binding (29), inhibition of CRH receptor transcription (30), inhibition of CRH/cAMP induced activation of Tpit/Pitx1, inhibition of CRH action via the Nur response element (12), and suppression of NeuroD1 expression which in turn inhibits the positive NeuroD1/E-box interaction in the POMC promoter (31)