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However, insulin signaling pathways that enhances GHR function or suppress IGFBP-1 or SHBG production are still intact and promote anabolism, optimize growth, enhance androgen actions and play a mechanistic role in premature adrenarche and PCOS

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doi: 10.1128/JVI.00755-21 34 GathererD.DepledgeD

5.1.4 Production of neurotransmitters The gut microbiota functions as an endocrine organ by producing various hormones and neurotransmitters that impact intestinal endocrine activity with the potential to regulate kidney function