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In the body, they function as signaling molecules, telling cells what to do

Despite the promising evidence from preclinical models, the effectiveness of HIF1a stabilizers as a future treatment for RA requires careful evaluation due to the pleiotropic and cell-type specific effects of HIF1a in RA pathogenesis

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Additionally, research has demonstrated that mutant HTT can interfere with histone acetyltransferase (HAT) activity, further reducing histone acetylation and leading to widespread transcriptional repression in neurons