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For instance, in cardiomyocytes, mitochondrial impairment may primarily disrupt energy production essential for cardiac contraction, while in neurons, it can lead to synaptic dysfunction and neurodegeneration [32]

Experiments have demonstrated that TCM formulas have significant efficacy in regulating the balance of pro-inflammatory and anti-inflammatory factors, reducing the level of oxidative stress, regulating autophagy and apoptosis, repairing the intestinal mucosal barrier, and regulating the balance of intestinal microorganisms, which are achieved by modulating the PI3K/Akt signaling pathway (Supplementary Table 2)

As discussed earlier, some cancers show low glutamine levels compared to benign adjacent tissues [36,37,38], raising a question about the rationale of this therapeutic approach (Figure 2)

References Adcock JL, Francis PS, Barnett NW (2007) Acidic potassium permanganate as a chemiluminescence reagent-a review

TB-500, in contrast, is a simplified synthetic analog representing the minimal active motif responsible for actin binding