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Brain tissues in hypertensive brain-injured rats exhibited changes in ferroptosis-relevant indicators, such as decreased expression of GPX4, glutathione (GSH), increased iron content and malondialdehyde (MDA)

Thus, results can vary

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The non-toxic metabolites are then excreted out of the body, and no harm, no foul

While control PPT NPs were not assessed for baseline activation, in vivo studies using 4T1 tumourbearing BALB/c mice revealed offtarget fluorescence from PPT@PTX 2 NPs in the liver, lungs, and kidneys, indicating nonspecific particle disassembly

first labeled TurboID or miniTurbo at the C-terminus of CTP synthase (CTPS) and then detected conformational changes in the CTPS filamentous structure