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4,5 These factors assist in the assessment of the potential for nevus transformation into melanoma, and they include thickness of 2 mm or more, presence of subretinal fluid, symptoms such as metamorphopsia and photopsia, orange pigment, margin within 3 mm of the optic disc, ultrasonographic hollowness, absence of halo, and absence of drusen

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Curr Opin Struct Biol 17:467473 Hilker I, Schaafsma AEJ, Peters RAH, Heise A, Nijenhuis AJ (2007) Insight into lipase-catalyzed formation of macrocyclic oligoesters