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The innovation involved constructing an efficient and specific catalytic system through GSH modification: (1) AA oxidase activity increased by 40%, and the Michaelis constant optimized to 0.189 mM, approaching natural enzyme levels
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However, during myogenesis, GW182 detaches and HDAC4 loses 5cap and poly(A) tail, suggesting that loss of GW182 alone or in combination with changes in HDAC4 facilitates the transport of Ago2: miR-1 into mitochondria ( Figure 8A )
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Most melanoma cells produce melanin, thus melanoma tumours are usually brown or black
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