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10.1016/j.cell.2011.02.013 Cell 41 HuS.FrankeR

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The use of a rat model, although widely accepted for preliminary biomedical research, may not entirely replicate the complex pathophysiological processes of premature ovarian insufficiency in humans

Additionally, using 31 P-MRS, we assessed in vivo changes in mitochondrial functioning by measuring several biological markers of cerebral energy metabolism during treatment