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Excessive amounts of n-3 and n-6 PUFAs triggered ferroptosis under acidosis, which mimics tumor microenvironment conditions 122

Sensitization of -lap-treated MiaPaCa2 cells by GLS1 knockdown was rescued by replenishing metabolic substrates of the glutamine metabolism pathway that are downstream of the GLS1 reaction, namely, oxaloacetate (OAA) or cell-permeable dimethyl malate (Fig
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The Role of Co-Factors For glutathione to work efficiently, it needs certain "helpers" or co-factors

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Cancer involves sustained, uncontrolled VEGF production