lipoic acid glutathione reductase as a protective agent against lipopolysaccharide and other natural toxins: a comprehensive review | Naunyn-Schmiedeberg's Archives of Pharmacology Glutathione reductase catalytic cycle |

Although increased detection might have played a major role, some evidences suggest that true increase in incidence have also contributed to such phenomenon

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Mitochondrial formyl peptides are elevated in ARDS patients (Yang and Hwang, 2016

Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R

Additional strategies aim to disrupt mitochondrial function through VDAC1 blockade or to reduce tumor hypoxia using hypoxia-activated prodrugs, hyperbaric oxygen therapy, and oxygen-transporting agents

Flunarizine in the prophylaxis of migrainous vertigo: a randomized controlled trial