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The high levels of intracellular calcium promote ROS generation and the release of apoptotic factors leading to cell death [114,115]

Available online at: August 11, 2025) A Randomized, Double-Blind, Placebo Controlled, Parallel Groups Study on Efficacy and Safety of nac 600 mg Daily and nac 1200 mg Daily as Mucolytic Agent in the Treatment of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Ren et al., 2018)

Combinations of nanoparticles with antibiotics offer numerous advantages, including reduced dosages for both drugs, which potentially decrease toxicity and enhance antimicrobial efficacy 13