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Besides inhibiting the Xc- antiporter, erastin is also an activator of the mitochondrial voltage-dependent-anion channel (VDAC) by reversing the inhibitory effect of tubulin on VDAC, thus increasing oxidative phosphorylation, ATP, ROS production and mitochondrial membrane permeabilization

Generally speaking, the H-site is built from elements from both the N- and C-terminal domains

In type II alveolar epithelial cells, TGF-1 lowered the transcriptional activity of GCLC [72]

It emphasises the urgent need for further research into the detailed mechanisms of sirtuin-microbiota interactions and their implications for preventing and treating metabolic disorders and liver cancer

Notably, vitamin D receptor (VDR) expression is widespread in renal tubular and vascular smooth muscle cells, and its signaling appears to exert both protective and potentially adverse effects (3, 5)

This disease entails a progressive impairment that notably impacts the lives of patients, their families, and caregivers, representing a high cost of treatment while disrupting their quality of life [2]