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54 While the MPC4 values of the analogs were not drastically improved compared to SLU-258, they showed favorable properties as potential EPIs including increased outer membrane permeability and being less prone to efflux

Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging

In contrast, deregulated regulatory networks would give rise to iron-dependent disorders including ferroptosis and closely implicated diseases, such as cancers, diabetes, and neurodegenerative diseases

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10.1158/1055-9965.EPI-20-0743 246 RajanK