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monthly for maintenance

Regulation of FOXO ubiquitination by Mdm2 is likely to be direct since Mdm2 and FOXO co-immunoprecipitate

Before surgery, the patients will undergo brain imaging studies using high-resolution MRI

178 This approach aims to streamline treatment adjustments and enhance long-term outcomes

Although these early approaches highlighted LNPs potential as nucleic acid delivery carriers, they are less suited for clinical application due to technological limitations

However, because the IOP-lowering effect of ROCK inhibitors is less potent compared to prostaglandin analogs (PGAs), they are primarily used as adjunctive therapies (19, 27)