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A key concern in cirrhosis is the potential for opioids to precipitate or exacerbate hepatic encephalopathy (HE)

Small peptides known as cell-penetrating peptides (CPPs) are derived from viral, insect, or mammalian proteins that can penetrate the cell membrane

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Glutathione has important functions in the antioxidant metabolism of the brain, but different cells in the brain have different requirements for glutathione precursors, which provide a defense against oxidation (Liu et al., 2018) via the Saposin C/GPR37L1/GPR37 pathway

Antonio-Nkondjio, C., Sandjo, N