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You miss out on the synergies between the constituents found in the whole plant or the full-spectrum extract, many of which we dont fully understand yet

doi: 10.1080/01480545.2020.1780251

Nevertheless, challenges such as low oral bioavailability and restricted CNS penetration necessitate further optimization of pharmacokinetics and the development of formulations

doi: 10.1136/postgradmedj-2020-138577

This is different from the reported Cm effectors, which all have enzymatic activity 39,75,76

Among structures not illustrated in Figure 7 are the adenine nucleotide transporter (ANT), which exchanges ATP in the matrix for ADP in the intermembrane space, and an importer for phosphate