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Description
Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes
Furthermore, mutations in SPINK5 have also been associated with atopic dermatitis [47], further highlighting the relevance of the Spint1a-deficient zebrafish model
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In line, lactate also accumulated to a higher extent in the culture medium of Gclc fl/fl Mb1-Cre + FoB as compared to control cells (Fig
650mg (as ascorbic acid) L-Glutathione Reduced
