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Kusari J, Zhou S, Padillo E, Clarke KG, Gil DW

Lewandowski E

doi: 10.1007/s11011-021-00788-3 25

The ferroptosis inducers such as glutamate, erastin are able to drain GSH and inactivate the enzymatic activity of GPX4 via blocking the import of cystine by the cystine/glutamate antiporter (system X c ) [27, 28] (Fig

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52,53 Enzymes such as protein kinase C (PKC), MAPK, and protein kinase A (PKA) modulate NOX activation, whereas the tumor suppressor p53 regulates both antioxidant and prooxidant responses, promoting ROS production and apoptosis in cancer cells
