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These modern tragedies point to a potential reason early humans evolved to possess dark skin, said Mel Greaves, a cell biologist at the Institute of Cancer Research in the United Kingdom

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Based on genetic studies exhibiting altered lipid phenotypes in gain- or loss-of-function mutations in the abovementioned proteins regulating LPL activity, pharmaceutical companies have targeted these proteins to develop novel therapeutics to treat hypertriglyceridemia in patients who do not reach the target goal of TG after using the currently available drugs

Hou L, Zhang Y, Zheng D, Shi H, Zou C, Zhang H, et al