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constructed an electrochemical aptasensor designed to undergo a conformational change upon cortisol binding [36]

In another study using rabbit Achilles tenocytes, the administration of IGF-1 led to the increased expression of type I collagen gene at 0.1 and 1 ng/mL, followed by a decrease at 10 ng/mL (Rieber et al., 2023)

Structure guided mutagenesis and homolog screening reveals hinT mutants with increased affinity HinT is highly conserved from bacteria to humans, including the hydrophobic and polar residues which form the adenine and phosphate binding pockets 28 .In contrast, the C terminus of hinT is highly variable among homologs and contributes to substrate specificity and catalytic function in vitro 34,37

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doi: 10.1007/s00216-007-1317-9