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While further studies are needed to assess longterm safety, dosing, and clinical relevance, the work points to a promising intranasal drugdelivery platform that emphasizes stability, retention, and neuroprotectionkey considerations for managing a chronic neurodegenerative disease
Hydroxypropyl-beta-cyclodextrins are well known pharmaceutical excipients, typically used in small molecule pharmaceutical formulations, primarily to increase solubility and bioavailability [T

The size and burden of mental disorders and other disorders of the brain in Europe 2010

How Medications Interfere with B12 Absorption Some medicines can lower vitamin B12 levels
PMID 20012068