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Specifically, acute and chronic prolonged wakefulness in mice induced by modafinil treatment produced LTP of glutamatergic synapses on hypocretin/orexin neurons in the lateral hypothalamus, a well-established arousal/wake-promoting center

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This suggests that AOD-9604 does not produce weight loss in a dose-dependent manner, a unique characteristic that deviates from the norm for many other drugs

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BPC-157 meets this criterion because its clinical development (PL 14736, Diagen) stalled at phase II in 2014 and never obtained registration as a drug